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tiomers and more information on this is available in the bibliography at the end of this chapter. The phenomenon of chirality is especially important in biochemistry because many biomolecules are chiral. In biological systems there is usually a selection for one of a pair of enantiomers. For example most amino acids in living systems are l-enantiomers with d-enantiomers occurring only very rarely (e.g. in antibiotic peptides). Similarly, most monosaccharides are d-enantiomers with l-enantiomers occurring rarely. By contrast, most chemical reactions carried out in solution result in a 50 : 50 mixture of d- and l-enantiomers. Chirality has several important consequences for the structure, shape and functional properties of biomolecules. For example, l-amino acids result in the right-handed helices observed in proteins. d-amino acids result in lefthanded helices which are themselves mirror images of righthanded helices while heteropolymers of a mixture of dand l-amino acids cannot form helices at all. Proteases are capable of hydrolyzing peptide bonds in polypeptides composed of all-l-amino acid substrates but cannot hydrolyze those of all-d composition. Conversely, synthetic proteases which can be made chemically with all-d-amino acids (e.g. the HIV protease) can cleave all-d polypeptide substrates but not those of an all-l amino acid composition. Indeed, the synthetic HIV protease is itself a mirror-image of the natural all-l enzyme showing that chirality is maintained throughout the hierarchy of protein structure. It has also been discovered that a pair of enantiomers may display distinct toxicity to humans with one enantiomer being toxic while the other is nontoxic. A well-known example of this is the fertility drug thalidomide which was widely

Physicists are happy in the belief that nature in its fundamental workings is essentially simple, but observed physical phenomena rarely exhibit overwhelming regularity Therefore, at the very same time that we construct a physical theory with intrinsic symmetry, we must nd a way to break the symmetry in physical consequences of the model 5 These problems have produced a theoretical impasse for over two decades, and in the absence of new experiments to channel theoretical speculation, some physicists have concluded that it will not be possible to make progress on these questions within eld theory, and they have turned to a new structure, string theory In eld theory, the quantized excitations are point particles with point interactions, and this gives rise to the in nities.

In general, the proposal should include a mission statement, the requested dollar amount, a description of how the money will be spent, information on reporting procedures, and evaluation techniques Other helpful information could include a board of directors list, previous years financial statements, and a listing of other major donors Again, the most important things to include in any proposal are the elements the foundation requested during the meeting..

NodeList list=newElem.getChildNodes(); for (int i=0;i<list.getLength();i++) { Node n=list.item(i); // Text node if (n.getNodeType()==Node.TEXT_NODE) { log.println( found text node ); String valStr=n.getNodeValue(); log.println( valStr== +valStr); valStr=XSQLUtil.resolveParams(valStr,pageRequest); log.println( valStr replaced == +valStr); n.setNodeValue(valStr); }

In string theory, the excitations are extended objects strings with nonlocal interactions; there are no in nities in string theory, and that enormous defect of eld theory is absent 6 Yet in spite of its positive features, until now string theory has provided a framework rather than a de nite structure, and a precise derivation of the standard model has yet to be given On previous occasions when it appeared that quantum eld theory was incapable of advancing our understanding of fundamental physics, new ideas and new approaches to the subject dispelled the pessimism Today we do not know whether the impasse within eld theory is due.

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Figure 37-2 A router ACL uses source and destination IP addresses and ports to allow or deny passage.

The purpose of risk treatment is to determine what will be done in response to the risks that have been identified, in order to reduce the overall risk exposure.

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Because the object, and not the variable, has the data type (for example, integer), a variable can reference a list at one moment and a floating-point number the next. An object s type can never change, but for lists and other mutable types its value can change.